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Zenegra (Sildenafil)

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Zenegra, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Zenegra is formulated as blue, film-coated rounded-diamond-shaped tablets equivalent to 25 mg, 50 mg and 100 mg of sildenafil for oral administration. In addition to the active ingredient, sildenafil citrate, each tablet contains the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and FD & C Blue #2 aluminum lake.

Other names for this medication:
Caverta, Intagra, Kamagra, Penegra, Revatio, Silagra, Sildenafil, Sildenafila, Sildenafilo, Sildenafilum, Sildigra, Suhagra, Veega, Zenegra

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Also known as: Sildenafil


Zenegra (sildenafil) relaxes muscles found in the walls of blood vessels and increases blood flow to particular areas of the body.

Zenegra is used to treat erectile dysfunction (impotence) in men. Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. This page contains specific information for Zenegra, not Revatio.

Do not take Zenegra while also taking Revatio, unless your doctor tells you to.


For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, VIAGRA may be taken anywhere from 30 minutes to 4 hours before sexual activity. The maximum recommended dosing frequency is once per day.

Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg.


If you overdose Zenegra (Pfizer) and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Zenegra are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Zenegra can interact with several other medications. Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe.

Zenegra and other medications

Below are lists of medications that can interact with Zenegra. These lists don’t contain all the drugs that may interact with Zenegra.

Before taking Zenegra, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Zenegra and other ED medications

You shouldn’t take Zenegra with any other medications for erectile dysfunction (ED). This includes prescription medications, such as:

  • tadalafil (Cialis)
  • avanafil (Stendra)
  • vardenafil (Levitra, Staxyn)
  • alprostadil (Muse, Caverject, Caverject Impulse, Edex)
It also includes natural or over-the-counter ED treatments, such as l-arginine and yohimbine.

Taking Zenegra with other ED medications increases your risk of certain side effects, such as low blood pressure and priapism.*

If you’re using Zenegra, don’t use any other medications for ED without talking with your doctor.

* Priapism is a long-lasting and sometimes painful erection that doesn’t go away. It’s a medical emergency because it can damage the tissues in your penis and lead to permanent ED.

Zenegra and nitrates

You shouldn’t take Zenegra with nitrate drugs. This includes certain prescription drugs, such as nitroglycerin, used to treat angina (a type of chest pain). It also includes certain illicit drugs called poppers, such as amyl nitrate.

Taking Zenegra with nitrates can cause a dangerous drop in your blood pressure that can lead to heart attack or stroke.

Examples of nitrate drugs that should not be taken with Zenegra include:

  • nitroglycerin (Nitromist, Nitro-Dur, Nitrolingual Pumpspray, Gonitro, others)
  • isosorbide mononitrate (Monoket)
  • isosorbide dinitrate (Dilatrate SR, Isordil)
  • glyceryl trinitrate
  • amyl nitrate
  • alkyl nitrate
  • butyl nitrate

Zenegra and drugs for pulmonary arterial hypertension

You shouldn’t take Zenegra if you’re taking the pulmonary arterial hypertension (PAH)* drugs listed below. Taking Zenegra with these medications can cause your blood pressure to drop too low.

Examples of drugs used to treat PAH that should not be taken with Zenegra include:

  • riociguat (Adempas)
  • sildenafil (Revatio)
  • tadalafil (Adcirca)
* With PAH, you have <em>high blood pressure</em> in the artery between your heart and lungs.

Zenegra and blood pressure drugs

Zenegra can sometimes cause low blood pressure. Taking Zenegra with drugs used to treat high blood pressure can cause your blood pressure to drop even lower.

Examples of drugs used to treat high blood pressure include:

  • calcium channel blockers, such as amlodipine (Norvasc)
  • beta-blockers, such as metoprolol (Lopressor, Toprol-XL)
  • ACE inhibitors, such as lisinopril (Zestril, Prinivil)
  • angiotensin II receptor blockers, such as losartan (Cozaar)
If you take a drug for high blood pressure, your doctor might prescribe a dose of Zenegra for you that’s lower than the typical dose.

Zenegra and alpha-blockers

If you’re taking a type of blood pressure drug called an alpha-blocker, the extra drop in blood pressure from Zenegra could make you feel dizzy or lightheaded. It could even make you faint. If you’re taking an alpha-blocker, your doctor will recommend a starting dose of 25 mg of Zenegra, which is lower than the usual starting dose.

Examples of alpha-blocker drugs used for high blood pressure include:

  • doxazosin (Cardura)
  • prazosin (Minipress)
  • terazosin
If you take one of the drugs listed above, tell your doctor if you feel dizzy or lightheaded, or faint after taking Zenegra.

Zenegra and illicit drugs

You shouldn’t take Zenegra with illicit drugs called poppers. Poppers contain nitrate drugs such as amyl nitrate, alkyl nitrate, and butyl nitrate. Taking Zenegra with poppers can cause a dangerous drop in your blood pressure that can lead to heart attack or stroke.

Zenegra hasn’t been tested for use with illicit drugs other than poppers. But it’s possible that taking Zenegra with certain other illicit drugs could also have dangerous effects on your heart and blood pressure.

Examples of illicit drugs that could have dangerous effects if taken with Zenegra include:

  • stimulants, such as cocaine, ecstasy, amphetamines, and speed
  • anabolic steroids
If you’re thinking of using illicit drugs with Zenegra, talk with your doctor about whether this is safe for you to do.

Zenegra and certain BPH drugs

Zenegra can sometimes cause low blood pressure. Certain drugs used to treat benign prostatic hyperplasia (BPH)* can also cause low blood pressure. These drugs are called alpha-blockers.

Taking Zenegra with alpha-blockers can cause your blood pressure to drop even lower. This could make you feel dizzy or lightheaded, or even cause you to faint.

Examples of alpha-blockers that are used to treat BPH include:

  • alfuzosin (Uroxatral)
  • doxazosin (Cardura)
  • tamsulosin (Flomax)
  • silodosin (Rapaflo)
  • terazosin
If you’re taking an alpha-blocker, your doctor will recommend a starting dose of 25 mg of Zenegra, which is lower than the usual starting dose. And if you take one of the drugs listed above, tell your doctor if you feel very dizzy, lightheaded, or faint after taking Zenegra.

* With BPH, you have an enlarged prostate.

Zenegra and Adderall

Zenegra hasn’t been tested for use with Adderall, so it’s not known what effects the drugs would have if taken together. But that doesn’t mean there wouldn’t be an interaction.

Adderall, which contains amphetamine salts, is approved to treat attention deficit hyperactivity disorder (ADHD). Adderall has stimulant effects in your body, and it could cause serious heart-related side effects.

Zenegra, on the other hand, may cause low blood pressure. So it’s possible that taking it with Adderall could have dangerous effects on your heart or blood pressure.

If you take Adderall, ask your doctor if it’s safe for you to take Zenegra as well.

Zenegra and Xanax

Zenegra hasn’t been tested for use with Xanax, so it’s not known what effects the drugs would have if taken together. But that doesn’t mean there wouldn’t be an interaction.

Xanax, which is a benzodiazepine, contains the active drug alprazolam. Xanax can sometimes cause low blood pressure, dizziness, and fainting. Zenegra may also lower your blood pressure. So it’s possible that taking it with Xanax could have dangerous effects on your heart or blood pressure.

If you take Xanax, ask your doctor if it’s safe for you to take Zenegra as well.

Zenegra and antidepressants

It’s usually fine to take Zenegra with antidepressants. It’s important to note that erectile dysfunction (ED) is a common side effect of certain antidepressants. This is particularly true for selective serotonin reuptake inhibitors (SSRIs), such as sertraline (Zoloft). And Zenegra is sometimes prescribed to treat ED that’s caused by antidepressants.

If you have questions about whether you can take Zenegra with an antidepressant, talk with your doctor.

Zenegra and certain antimicrobials

Taking Zenegra with certain antimicrobials (drugs used to treat infection) can slow the breakdown of Zenegra in your body. This can cause Zenegra to build up inside your body, which may increase your risk of side effects from the drug.

Examples of antimicrobial drugs that can increase the risk of side effects from Zenegra include:

  • certain antibiotics, such as:
    • clarithromycin
    • erythromycin
    • telithromycin (Ketek)
  • certain antifungals, such as:
    • ketoconazole (Nizoral)
    • itraconazole (Sporanox)
    • posaconazole (Noxafil)
    • voriconazole (Vfend)
  • certain antivirals used for HIV, such as:
    • atazanavir (Reyataz)
    • cobicistat (Tybost)
    • ritonavir (Norvir)
    • indinavir sulfate (Crixivan)
    • nelfinavir mesylate (Viracept)
    • saquinavir mesylate (Invirase)
If you take one of the drugs listed above, your doctor will recommend you take a starting dose of 25 mg for Zenegra. (This is lower than the typical starting dose of Zenegra.) And if you take ritonavir, you shouldn’t take more than one 25-mg dose of Zenegra within a 48-hour period.

Zenegra and herbs and supplements

There aren’t any herbs or supplements that have been specifically reported to interact with Zenegra. However, you should still check with your doctor or pharmacist before using any of these products while taking Zenegra.

Zenegra and foods

There aren’t any foods that have been specifically reported to interact with Zenegra. If you have any questions about eating certain foods with Zenegra, talk with your doctor.

Zenegra and grapefruit

Grapefruit juice can affect the levels of some medications in your body. But there’s not much evidence to show that the fruit or its juice can affect Zenegra levels.

One small study was done in 2002. It showed that drinking grapefruit juice with Zenegra slightly increased people’s blood level of the drug. This could possibly increase the risk of certain side effects such as headaches, flushing, or dizziness. But these side effects weren’t specifically reported in the study.

If you want to drink grapefruit juice or eat grapefruit while you’re taking Zenegra, talk with your doctor. They can recommend whether this is safe for you to do. If you do have increased side effects with this combination, try avoiding grapefruit while you’re taking Zenegra.

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Electron microscopy identified granules of Langerhans (Bierbeck), multiple tubulo-vesicular structures, ring-like plates, Golgi apparatus, lysosomes and dendritic processes. After spatial normalization, a reversed copy of the 13 scans was obtained, resulting in 26 scans which were assigned to two groups: a group with left-sided centrotemporal spikes and a group with right-sided centrotemporal spikes. C1-esterase inhibitor (C1-Inh) therapy was introduced in clinical medicine about 25 years ago as a replacement therapy for patients with hereditary angioedema caused by a deficiency of C1-Inh. Conjugates consisting of stigmasterol and L-phenylalanine, interconnected through short-chained dicarboxylic acyls by ester and amide bonds, respectively, were synthesized as potential low molecular weight/mass organic gelators (LMWGs/LMMGs). This method, which may be called SASA-scaled atomistic method, gave satisfactory results when compared with the original method of estimating log P from atomic parameters. To extract and identify the chemical constituents of essential oil from Lonicera fulvotomentosa in different collected periods (bud, Silver-flower and Golden-flower periods). falcatula can be differentiated with these markers and that multiple Sarcocystis spp., including S. Together, these findings demonstrate several ways that the risk-assessment strategies could be important in establishment and post-establishment dynamics of invasive prey. Both serum markers and imaging-based tissue elastography predict the presence of advanced fibrosis compared diflucan yeast infection reviews with liver biopsy.

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The issue of inherited disorders and poor health in pedigree dogs has been widely discussed in recent years. In addition, comparative information on gene structure and map location will help define the functions of essential genes. At that instant a maximum dose of valium daily rapid plantar flexion starts, reinforced by a strong increase of activation of gastrocnemius. Crystallization of a covalently-linked complex of adrenodoxin and adrenodoxin reductase. Circulating biomarkers of collagen turnover reflect extracellular cardiac matrix (ECCM) remodelling.

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Insertion of these catheters can be achieved either by using the anatomical landmarks for the veins into which they are inserted or using ultrasound guidance. This type of surgery has a surprisingly low morbidity and mortality at specialized centers. This therapeutic strategy demonstrates that aggressive incidents can be dealt with safely without recourse to seclusion. The objective of this study was to evaluate the in vivo anti-inflammatory angiogenesis activity and in vitro cytotoxicity on normal and cancer cell models of a drug delivery system consisting of poly(lactic-co-glycolic acid) nanofibers loaded with daunorubicin (PLGA-DNR) that were fabricated using an electrospinning process. The exact substrate of GrB in vivo is still unknown, but to induce apoptosis GrB requires the activity of caspases in target cells. For girls, early perceived pubertal timing was more strongly associated with emotional symptoms among those who often felt lonely. Effect of microcapsule size and polyisobutylene concentration on the release of theophylline from ethylcellulose microcapsules. In this work, we have modeled irreversible diffusion limited cluster aggregation of binary colloids, which serves as a model for chemical gels. There is a high need to build capacity cordarone 200 mg generic across most sectors for meeting the needs of youth with co-occurring mental health and substance use problems, especially for transition-aged youth.

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This article reviews the use of abdominal wall blocks in pediatric regional anesthesia. Mechanical information service of biomedical literature at the Library of the Hungarian Academy of Sciences. In dogs suffering from a spontaneous osteosarcoma, the loss of substance produced plavix medication other names by excision was filled with cement to which methotrexate had been added extemporaneously. The aim of this study was to compare the roentgenological and scintigraphic osseous changes in 25 resp. These internally validated MR-based nomograms were able to accurately predict TPSB outcomes for prostate cancer, especially significant disease. Sera from patients with IgA nephropathy were purified by heparin-affinity chromatography, and column eluate were analyzed for the presence of fibronectin using Western blot and a set of anti-fibronectin monoclonal antibodies. As time elapsed, the axon tube seemed to be filled with glial cells, but interposed small profiles of the original axon could be identified by injection of a fluorescent dye into the axon.

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Electrochemical Interrogation of G3-Poly(propylene thiophenoimine) Dendritic Star Polymer in Phenanthrene Sensing. During early limb development, distal tip ectoderm is induced by the underlying mesenchyme to form the apical ectodermal ridge. Inflammation caused gel contraction, with release of a watery liquid from the gel, and increases in the amount of insoluble material and high-molecular-weight components of the vitreous collagen, presumably due to extensive cross-links of the collagen molecules. We have used soluble tetrameric complexes of HLA class I molecules complexed with HIV epitope peptides to study the dynamics and frequency of HIV-specific CD8 T cells in relation to plasma viral load in early HIV infection, in three patients with a highly focused HIV-specific CTL response. Distribution of alpha-vascular smooth muscle actin in the smooth muscle cells of the gastrointestinal tract of the chicken. The 12.6-kb distant upstream tcpA promoter responsible for expression of the TCP operon has been proposed to provide an alternate toxT message by readthrough transcription. Traditional entomological methods of estimating postmortem interval from developmental stages of fly larvae associated with the body are based on the premise that older larvae are not recruited from the surrounding environment.

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Densitometric analysis is zyrtec d safe to take while breastfeeding of AT1 expression in APA showed no significant differences compared with normal and non-tumorous adrenal. All surviving patients are alive and free from symptomatic recurrence. The relationship between these blood pressure indices and risk of CH D over a 20-year follow-up period were then evaluated. Considering the age and symptoms of the patient, we did not perform any intervention, but continued surveillance with duplex ultrasonography in case of the high incidence of aneurysmal formation or thromboembolic event. The RNA is characteristically extended and bound in this cleft, where the UGUUUUUUU sequence is specifically recognized by the protein. Recipient liver volume (RLV) was defined as weight of liver explant after all attached ligaments, portal structures, and gallbladder were dissected free. We report a case of acquired segmental megacolon and constipation necessitating surgical colonic resection in an adult patient with CF.

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Carcinogenesis by derivatives of 1-nitroso-3,5-dimethylpiperazine in rats. A number of investigators have recently claimed, based on both analysis from transport theory and transport-theory-based Monte Carlo calculations, that the diffusion coefficient for photon migration should be taken to be independent of absorption. Recent advances that help to explain the pathogenesis of amyloidosis are summarized. Both patients were found to have proximal stenosis of the right coronary artery at cardiac catheterization. These data indicate that omentin promotes endothelial cell function and revascularization in response to ischemia through its ability to stimulate an Akt-eNOS detrol medication reviews signaling pathway. At the physical examination, we found a temperature of 37.4 degrees C, no rales, no crackles at auscultation of the lung, bilateral ankle edema and livid, pressure-dolent skin changes at the lateral margins of both feet.

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We compared resident physicians and respiratory care practitioners (RCPs) to a standard threshold of 1 attempt per successful intubation. lateralis thalami pars posterior) to the dorsal subiculum, respectively. Experimental Study of Cement - Sandstone/Shale - Brine - CO2 Interactions. Strengthening fairness, transparency and accountability in health care priority setting at district level in Tanzania. Comprehensive knowledge regarding Saccharomyces cerevisiae has accumulated over time, and today S. Two patients, members of the same family, were found to have entrapment of the suprascapular nerve from a calcified superior transverse scapular ligament. Surgical procedures consist of lymph node clearance, dissection of the distal bile duct, skeletonization resection of the hepatoduodenal ligament, mobilization of the liver and liver resection, dissection of the intrahepatic bile ducts, and biliary reconstruction. This article describes current knowledge on the structure, enzyme activity, and antigenic significance of neuraminidase. Recent attempts to use these polymers as the basis for chemosensors are highlighted. The software also produces annotation statistics to allow users to visualize how many coordinates were found within various portions of genes.

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Extragonadal yolk sac tumors of the gastrointestinal tract are extremely rare neoplasms. We previously found that retinoblastoma (RB) is cleaved at the initiation of apoptotic execution. Examination included assessment of lower extremity active range of motion, transfers, mobility, and completion of the Functional Independence Measure for Children (WeeFIM). Subsequent signal transduction pathways have been identified which result in the increased transcription of host defense response genes. Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD. SAW devices may be configured as strain sensors, providing passive, wireless strain measurement in demanding conditions. Bone-grafting also enhanced the formation of a soft-tissue capsule around the prosthesis.

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