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Alrest (Clonazepam)

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Alrest is used to prevent and control seizures. This medication is known as an anticonvulsant or antiepileptic drug. It is also used to treat panic attacks. Alrest works by calming your brain and nerves. It belongs to a class of drugs called benzodiazepines.

Other names for this medication:
Almac, Azpax, Catier, Clonatrac, Clonax, Clonaxyl, Clonazepam, Cloneepam, Clonotril, Closis, Clotas, Clotweet, Cozil, Easyfeel, Ection, Eminaz, Escimax, Escitacalm, Esitor, Estalonix, Ezinite, Jasoclam, Lonazep, Lonipax, Lozep, Meloprax, Melzap, Nazee, Onapil, Prasilex, Repam, Somnotril, Xenotril, Xitzen, Zeficar, Zepam, Zicam

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Also known as: Clonazepam


Alrest is an anti-anxiety medication in the benzodiazepine family, the same family that includes diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan), flurazepam (Dalmane), and others. Alrest and other benzodiazepines act by enhancing the effects of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter (a chemical that nerve cells use to communicate with each other) that inhibits brain activity. It is believed that excessive activity in the brain may lead to anxiety or other psychiatric disorders. Alrest is primarily used for treating panic disorder and preventing certain types of seizures.

Alrest is useful alone or as an adjunct in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. In patients with absence seizures (petit mal) who have failed to respond to succinimides, Alrest may be useful.


Adults. The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. Maximum recommended daily dose is 20 mg. The use of multiple anticonvulsants may result in an increase of depressant adverse effects. This should be considered before adding Alrest to an existing anticonvulsant regimen.

Pediatric Patients. Alrest is administered orally. In order to minimize drowsiness, the initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day but not to exceed 0.05 mg/kg/day given in two or three divided doses. Dosage should be increased by no more than 0.25 to 0.5 mg every third day until a daily maintenance dose of 0.1 to 0.2 mg/kg of body weight has been reached, unless seizures are controlled or side effects preclude further increase. Whenever possible, the daily dose should be divided into three equal doses. If doses are not equally divided, the largest dose should be given before retiring.

Geriatric Patients. There is no clinical trial experience with Alrest in seizure disorder patients 65 years of age and older. In general, elderly patients should be started on low doses of Alrest and observed closely.


Treatment after Overdose. If a person accidentally overdoses on Xanax, Valium, or Alrest due to interactions with prescription medications, this is unlikely a sign of addiction or abuse. However, if the overdose was the result of benzodiazepine abuse of any kind, help is needed.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Side effects

The most common side effects associated with Alrest are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


The elderly metabolize benzodiazepines more slowly than younger individuals and are also more sensitive to the effects of benzodiazepines, even at similar blood plasma levels. Doses for the elderly are recommended to be about half of that given to younger adults and are to be administered for no longer than two weeks. Long-acting benzodiazepines such as Alrest are not generally recommended for the elderly due the risk of drug accumulation.

The elderly are especially susceptible to increased risk of harm from motor impairments and drug accumulation side effects. Benzodiazepines also require special precaution if used by individuals that may be pregnant, alcohol- or drug-dependent, or may have comorbid psychiatric disorders. Alrest is generally not recommended for use in elderly people for insomnia due to its high potency relative to other benzodiazepines.

Alrest is not recommended for use in those under 18. Use in very young children may be especially hazardous. Of anticonvulsant drugs, behavioural disturbances occur most frequently with Alrest and phenobarbital.

Doses higher than 0.5–1 mg per day are associated with significant sedation. Alrest may aggravate hepatic porphyria. Alrest is not recommended for patients with chronic schizophrenia. A 1982 double-blinded, placebo-controlled study found Alrest increases violent behavior in individuals with chronic schizophrenia.

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