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Alpranex (Alprazolam)

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Alpranex is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alpranex, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alpranex is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Acalm, Alprastan, Alprowon, Alproz, Altin, Alzocum, Alzonex, Ambulax, Anlzium, Anxilam, Anxit, Calmef, Cozac, Depflu, Dipra, Dizeral, Ecsit, Fluwel, Pranol, Prazil, Prozam, Romipraz, Rozin, Selamb, Sertamax, Sowel, Stresnil, Tenschem, Texidep, Unixl, Wycalm, Xycalm, Zamitol, Zeecam, Zenax, Zepro, Zolin, Zolyde, Zopic

Similar Products:
Motilium, Zovirax, Geodon, Arava, Coumadin, Nokzok, Craveril, Zymycin, Emvate, Flavate, Docvir,

Also known as: Alprazolam


Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alpranex. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alpranex XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alpranex XR dosage information

Side effects

The most common side effects associated with Alpranex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Before taking Alpranex, tell your doctor or pharmacist if you are allergic to it; or to other benzodiazepines (such as diazepam, lorazepam); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: severe lung/breathing problems (such as COPD, sleep apnea), liver disease, kidney disease, drug or alcohol abuse, glaucoma.This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Older adults may be more sensitive to the side effects of this drug, especially loss of coordination and drowsiness. These side effects can increase the risk of falling Alpranex is not recommended for use during pregnancy due to the potential for harm to an unborn baby. Consult your doctor for more details.This drug passes into breast milk and may have undesirable effects on a nursing infant. Therefore, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

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Perseverance tendency in patients with generalized convulsive seizures and with partial seizures with complex symptoms. Duodenal diverticula are common, but perforated duodenal diverticulum is rare. hPGC-1-mediated enhancement required the receptor hormone-binding domain and was dependent on agonist ligands. Isolation of a T-cell line specific for hepatitis B core antigen from a patient with serological evidence of exposure to HBV. The goitres in the mares and the high blood levels of iodine decreased. An absorbable pinned-ring device for microvascular anastomosis of vein grafts: experimental studies. Transformations of hand movements by tools such as levers or electronic input devices can invoke performance costs compared to untransformed movements. When EGFR-positive cancer cells and Kit-positive hematopoietic cells were mixed and exposed to the different engineered vector particles, the cancer cells were selectively transduced by the SCF-displaying vector and the hematopoietic cells were selectively transduced by the EGF-displaying vector. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age. The chimeric RC-LH1 complexes were also functional, supporting bacterial growth under photosynthetic conditions.

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Comparative hygienic and bacteriologic studies in 35 dental practices. Indeed, the maximum force (tenacity) supporting the flotation of fine spheres was conjectured to occur when the apical angle of the contact circle is equal to the contact angle. Diagnosis of pure and mixed anaerobic infections in obstetrics and gynecology. In vivo activity was evaluated for dimethyl hydrazine-induced colorectal cancer in albino male Wistar rats. However, significant advances have furthered our understanding of the mechanisms involved in development, progression, and treatment of cardiovascular disease. Good within-subject 48-hr replicability indicates that individual resting state rCBF reflects fairly stable, subject-specific factors. We tested this approach using cadaveric dissection, then we performed the technique on a series of 21 patients from October 2009 to July 2010. Abstracts of trials presented at the Vth World Congress of Psychiatry (Mexico, 1971): a cohort study. Most randomized trials of these drugs exclude patients with CKD, and current guidelines for management of these patients are largely based on these trials. Characterization of and correction for artifacts in linogram MRI.

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In vivo oxygen amperometry measurements in the ventral striatum in awake, behaving rats reveal reward-related tissue oxygen changes that closely parallel blood oxygen level dependent (BOLD) signal changes observed in human functional magnetic resonance imaging (fMRI), suggesting that a cross-species approach targeting this mechanism might be feasible in psychopharmacology. The reported consumption of breakfast cereals, bread, fruit juices, ice cream, and nuts and crackers was not associated with high DMFT scores, perhaps because they were consumed only infrequently. The results were then compared with the patterns obtained by ribotyping with HindIII, KpnI, and XbaI restriction enzymes. Regulated exocytosis in immune function: are SNARE-proteins involved?. Changes in these factors can cause microbiome disruption known as dysbiosis, leading to the outgrowth of potential pathogenic bacteria or a decrease in the number of beneficial bacteria. The procedure, in its infancy, appears to be beneficial to patients with severe dilated cardiomyopathy.

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Backbone dynamics of Fusarium solani pisi cutinase probed by nuclear magnetic resonance: the lack of interfacial activation revisited. To investigate the influence of the developing host environment on the integration and morphological and molecular differentiation of MSCs, human bone marrow-derived mesenchymal stem cells (BM-MSCs) were transplanted into the developing mouse retina. alpha 1AT transcripts are also present, albeit at a lower level, in a variety of other human tissues. A proteasome inhibitor, an antioxidant, or a salicylate, but not a glucocorticoid, blocks constitutive and cytokine-inducible expression of P-selectin in human endothelial cells. The ability of DEDC to covalently cross-link proteins in vivo and to produce axonal structural changes identical to those produced by CS2 is consistent with release of CS2 from DEDC being a contributing mechanism in DEDC-induced neurotoxicity. After drug selection, the resulting neural cell lines (SCN1.4 and SCN2.2) displayed (a) extended growth potential without evidence of transformed or tumorigenic properties, (b) expression of E1A protein within all cell nuclei, and (c) heterogeneous cell types in various stages of differentiation. The proposed HPLC assay was utilised to directly evaluate the capability of P-glycoprotein expressing multidrug resistant cells in mediating the transport and efflux of protease inhibitor (PI) Indinavir, a basic compound in AIDS care. In the closed-loop HPLC-NMR system, degradation or isomerization of separated compounds is largely hindered. The primary focus of this review is to summarize the main systemic associations of NAFLD, as well as to discuss the mechanisms that link them to NAFLD. In open treatment of adolescent MDD with sertraline, significant improvement occurred early on and was maintained for 22 weeks.

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Meta-analyses were done using the relative age-specific mean D(M)FT difference between girls and boys. Bile duct injury is one of the potential severe complications that can occur during laparoscopic cholecystectomy, which can be cause by anatomic variations in the confluence of the depakote starting dose bipolar bile duct. Moreover, several samples were randomly selected to validate the gene polymorphisms of cx40 and AT1. This method is applicable to the introduction of various carboxylic acid-containing compounds into the N-terminus of peptides, which will be useful not only for improvement of MS/MS fragmentation but also for various biochemical studies of peptides and proteins. Two-dimensional polyacrylomide gel electrophoresis (2D gel, 2D PAGE, 2-DE) is a powerful tool for analyzing the proteome of a organism. Transgenic mice overexpressing LIF have mesangial proliferative glomerulonephritis.

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GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR IMPROVES IMMUNOGENECITY OF HEPATITIS B VACCINE IN HEMODIALYSIS PATIENTS. There were no adverse effects on high-density-lipoprotein cholesterol, nor any consistent associations with plasma triglycerides. Specimens were also examined for mast cell numbers and degree of inflammation. The use of a two-dimensional polyacrylamide gel electrophoresis joined with Western blotting allowed us to investigate the reactivities of antibodies present in sera from mice and humans to antigens of Candida albicans blastoconidia. To establish the cell type expressing leptin, we also assessed the size and organization of lipid droplets, the ultrastructural features of mitochondria, and the presence or absence of uncoupling protein, a brown fat-specific marker.

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Inflammatory diseases are associated with the accumulation of activated inflammatory cells, particularly polymorphonuclear neutrophils (PMNs), which release reactive oxygen species (ROS) to eradicate foreign bodies and microorganisms. Transport factor refers to the transport of radionuclides on transportation arteries and the transfer of these agents to the human population residing in the vicinity of these arteries. Exposure to formaldehyde and phenol during an anatomy dissecting course: sensitizing potency of formaldehyde in medical students. The difference between Japan and other countries, in particular the United Kingdom, in views regarding the teaching of geriatrics to undergraduate medical students. Logistic regressions were conducted to identify the risk factors for viral load rebound. To evaluate the reliability and validity of simplified Chinese version of the SAQ (SC-SAQ). Expression of leukemia inhibitory factor by cartilage-forming tumors of bone: an immunohistochemical study. Lymph nodes in the region of the mandible, jugular veins bilaterally and mediastinum were noted for the first time, remaining unchanged in size over six months. Splenic lymphangiomatosis is often an incidental imaging finding that frequently has a characteristic imaging appearance.

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Apolipoprotein E Mediates Evasion From Hepatitis C Virus Neutralizing Antibodies. Although striatal neurons receive continuous dopamine (DA) input, little information is available on the role of such input in regulating normal striatal functions. To study the effects of beta-adrenergic agents on intracellular potential (Vm) of the isolated and intact rabbit ciliary epithelium. In our study, 1 in 5 HIV-infected women with no evidence of cervical disease developed biopsy-confirmed SILs moduretic drug class within 3 years, highlighting the importance of cervical cancer screening programs in this population. Alginate-Poly(ethylene glycol) Hybrid Microspheres for Primary Cell Microencapsulation. Nowadays, non-nucleoside DNMT inhibitors are in development to address high toxicity of nucleoside analogs.

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Effects of hyperprolactinemia on plasma prolactin and glucose and on local cerebral glucose utilization. The effect of neostigmine on suxamethonium induced neuromuscular block in the dog. Actinomycosis in trileptal medication price a patient treated for maxillary osteoradionecrosis. The relationships between eating and drinking habits, and serum as well as 24-hour urinary concentrations of calcium, inorganic phosphate uric acid and urinary pH were studied in 379 patient in whom stones form. Then, lysates from GFP-TgAtg8 tachyzoites were directly subject to large-scale tandem affinity purification with anti-GFP antibody. We also analyzed some examples of time series from patients using power spectrum estimates in order to validate the low level QT interval variability.

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Association between Earlier Age of Sexual Initiation and Worse Adolescent Health and Well-being Outcomes. And among them 8 such species have been recorded in fishes of the Volga-Caspian region. To assess overall perioperative and anesthetic care-specific patient satisfaction. The low-threshold dendrotoxin-sensitive sustained potassium current (IDS) is associated with principal cells klonopin 10 mg picture that accommodate and is not expressed in those that fire repetitively. It must be differentiated from known causes of granulomatous inflammation, such as tuberculosis.

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