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Adiff (Adapalene)

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Adiff is a retinoid. While experts aren't exactly sure how it treats acne, they believe it works by stopping pimples from forming under the skin and lowering the amount of redness and inflammation on the skin.

Other names for this medication:
Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Apalene, Apgel, Clinred, Daple, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Lunesta, Elavil, Prilosec, Cycrin, Vasotec, Ceftin, Estrace, Zyprexa, Imitrex, Adglim, Sysron, Celira, Elition, Gluconorm, Agiclob,

Also known as: Adapalene


Adapalene is used to treat acne. It works partly by keeping skin pores clear.

Adapalene is available only with your doctor's prescription.


Follow the directions for using this medicine provided by your doctor. Use Adiff exactly as directed. Adiff is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Adiff. Adiff should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Adiff. Continue using Adiff until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Adiff promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Adiff dosage information

Side effects

The most common side effects associated with Adiff are:

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We theorize that this effect is due to the complex interaction of residential discrimination, racism, age of drinking, and lack of available standard life reinforcers (e.g., stable employment and financial stability). This study aimed at investigating whether migraine patients present an altered response to NO also in the peripheral artery system. Measurements and modeling of DO2 formation in the reactions of C2D5 and C3D7 radicals with O2. After manual reduction for an incarcerated hernia and left inguinal herniorraphy, the left testis was fixed into the left hemiscrotum and right transseptal orchiopexy was performed. In all imaging systems, proper illumination is crucial for attaining optimal image quality that is needed for the best performance of image analysis algorithms. In recent years there have been advances in the non-surgical management of testicular pain mainly because of the emergence of pain relief as a specialty. To investigate the protective effect of hydroxysafflor yellow A (HSYA), a soluble element extracted from Carthamus tinctorius L., on focal cerebral ischemia in rats.

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This phenomenon was studied in fed-batch culture under optimal operating conditions, with a mineral medium and using glucose as carbon source. The authors describe stress fracture of the second metacarpal bone in teenaged tennis players and the relationship with sport intensity and type of grip used. The purpose of the study was to investigate if the protocol could be simplified such that (i) a reduced number or even a single extraction technique could be used and (ii) a reduced number of solvents could be used to obtain information that is useful for material selection regardless of product type. By adhering to local guidelines, continuous education, and other practical interventions, the burden of resistance can be alleviated, as highlighted in this survey. Finally, the observation that hypo-phosphorylated capsid binds Bax just as well as wild-type capsid protein suggests that interaction with this pro-apoptotic host protein in and of itself is not sufficient to block programmed cell death. The lung was the most common primary site for jawbone metastases, whereas the liver was for those of oral soft tissues.

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Pulse wave velocity as an accepted surrogate marker of the cardiovascular risk is assessed in both study groups. Here we aimed to assess the effect of long-term storage on preservation and viability of cryopreserved human ovarian tissue. C-reactive protein is the widely used marker in a clinical practice but also a mediator of the inflammatory process. Data on adverse drug reactions, hypoglycemia and glycemic control were collected at baseline, week 12 and 24. This prospective pilot study investigated the dynamics of LS during the perioperative valve operation period. However, there are very few reports on the molecular profiles of small cell lung cancers (SCLCs). Heart rate variability and circadian variations in type 1 diabetes mellitus. There was significant biofilm formation in the control tube relative to the samples. Neuroimaging studies of learning focus on brain areas where the activity changes as a function of time. Many patients have poor tolerability to therapy, necessitating alternative treatment options.

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RNAi-mediated gene silencing provided direct evidence for the role played by this protein in the immune response. Surface potential mapping is performed and a current model for such a heterojunction is proposed. Long-term impact of hydrological regime on structure and functions of microbial communities in riverine wetland sediments. We also show how in this model the quasi-stationary kinetics of assembly can be described as a Markovian cascading process, in which only a few intermediates and a small proportion of pathways are present. Although gastric cancer with isolated para-aortic lymph node (PAN) involvement is considered an advanced disease, the clinical characteristics of it have not been comprehensively elucidated.

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The emergence and spread of antibiotic resistance among human pathogens is a relevant problem for human health and one of the few evolution processes amenable to experimental studies. The extent to which an age-dependent decline in androgen levels leads to health problems that might affect or alter the quality of life remains under debate. To define the prognostic value of evaluation exercise-induced myocardial ischemia according to the data of pharmacological (dobutamine or dipyridamole) stress echocardiography (EchoCG) in patients with acute coronary syndrome (ACS). Hence the C52L fusion inhibitor may find a practical application, for example as a vaginal or rectal microbicide to prevent HIV-1 infection in the developing world. CD5-positive B-cell acute lymphoblastic leukemia (ALL) is an exceedingly rare entity, with only a single case report in the literature. PARP expression was detected by immunohistochemistry using monoclonal antibodies, scored by the multiplicative quickscore (QS) method and compared to PARP expression in normal testicular tissue.

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Synthesis of 5-pyridyl-2-furaldehydes via palladium-catalyzed cross-coupling with triorganozincates. Phenol-grown CF600 transformed phenylacetylene to hydroxyphenylacetylene and 2-hydroxy-6-oxo-octa-2,4-dien-7-ynoic acid as detected by gas chromatography--mass spectroscopy and high-performance liquid chromatography (HPLC), respectively, while neither a derivative of CF600 with a non-functional phenol hydroxylase nor wild-type CF600 grown on acetate transformed phenylacetylene. Optical tweezers-based nanometry was used to measure the myosin-1b step-size directly. Allergy is initiated by a very specific IgE-dependent mechanism, but involves a late phase corresponding to non-specific inflammation. By immunohistochemistry, NAV3 expression was most evidently enhanced in degenerating pyramidal neurones in the cerebral cortex of AD. A number of algorithms has been developed to initiate warfarin therapy. Thyroxine was simultaneously given in drinking water (0.2 or 2.0 mg/l) for 14 weeks. This study was undertaken to investigate whether CNP signaling could prevent growth delay and cartilage damage in an animal model of inflammatory arthritis. Effect of daily environmental temperature on farrowing rate and total born in dam line sows. veterans of the Vietnam war, who were exposed to dioxin during herbicide-spraying operations, are studied.

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Early lesions of the labrum and acetabular cartilage in osteonecrosis of the femoral head. Plantations of non-native, fast imovane dosage pbs -growing trees are increasing in the tropics and subtropics, perhaps with negative consequences for the native avifauna. cepacia biofilms formed on various prosthetic materials was tested. Although a number of factors involved in radioresistance have been identified, the molecular mechanisms underlying radioresistance of esophageal squamous cell carcinoma (ESCC) have not been elucidated. Use of DALYs in economic analyses on interventions for infectious diseases: a systematic review. Primary prevention implantable cardioverter-defibrillators in older racial and ethnic minority patients. Tacrolimus treatment in periodontitis-induced rats conferred protection against the inflammation-induced tissue and bone loss associated with periodontitis, through a mechanism involving IL-1beta, TNF-alpha and IL-6. Regional differences in bioavailability of an opioid tetrapeptide in vivo in rats after administration to the respiratory tract.

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Studies on the fine structure of the nucleolus and the nucleolusorganizing region in Gnetum gnemon. The evaluation of personality dimension in EDs has therapeutic and prognostic implications: To enhance self-efficacy and self-directness is crucial for good clinical outcome. D5S1028 was the only non-MTS marker which showed an informative diagnostic capability. aneuploidy) due to abnormal chromosome segregation may arise either spontaneously or as a result of chemical/radiation exposure, particularly during cell division. This case highlights the rarity of pure blowout fractures in young children. Those loci with the highest discriminatory power were subsequently selected. The intraradiopraxis with (90)Y glass microsphere would be a valuable method for patients with hypo-leukocyte count, insensitive to chemotherapy or resistant to chemotherapy. Cells collected by peritoneal washing were reinfused into the peritoneal cavity of the same animal after zovirax dosage genital herpes irradiation. This in turn triggers downregulation of superoxide dismutase and catalase (CAT) activities that have essential roles in oxidative detoxification in mammals.

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Simultaneous quantification of isoniazid, rifampicin, ethambutol and pyrazinamide by liquid chromatography/tandem mass spectrometry. The isolate showed in vitro phenotypic switching that may affect virulence and host inflammatory and immune responses, and in vitro resistance to amphotericin B and 5-flucytosin. In addition, we review data obtained in clinical studies involving HDACIs and we discuss how such agents might be beneficial for the treatment of cancer. The present study was a fine-grained analysis of the temporal relationship between alcohol use and short-term mood-switching probabilities. Elucidation of multiantifungal resistance mechanisms in pathogenic fungi and their clinical impacts. All-Cause Mortality Associated with Tumor Necrosis Factor-Alpha Inhibitor in Patients with Rheumatoid Arthritis.

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